The antidepressant doxepin (originally marketed by Pfizer under the brand name Sinequan) is a tricyclic antidepressant approved to treat anxiety disorders. As a medication in this class, doxepin (Sinequan) has a number of possible side effects. Not all people who take the medication will experience side effects, and the duration and severity can also vary between individuals.
Common Side Effects
The most common side effects of doxepin include drowsiness, dizziness or lightheadedness, nausea, constipation, difficulty urinating, dry mouth, weight gain, changes in libido or sexual function, changes in blood sugar levels, and excess sweating.
Serious Side Effects
Severe side effects are rare, but if they occur require immediate medical attention. Serious side effects of doxepin use may include allergic reaction, behavior changes, abnormal thoughts, fainting, hallucinations, sore throat or fever, mood changes, difficulty speaking and swallowing, chest pain, seizures, twitching of the face or tongue, a heartbeat that is fast, slow or irregular, unusual bleeding and bruising, jaundice, and suicidal thoughts.
While many people tolerate doxepin well, it is impossible to know beforehand whether you will experience side effects while taking the medication. Any side effects that are serious or bothersome should be reported to your doctor, so your doxepin dosage can be adjusted or the medication can be discontinued if necessary.
