Medication Overview of Norpramin

Norpramin is a brand name for the pharmaceutical desipramine, a tricyclic antidepressant which operates by inhibiting the reuptake of norepinephrine and serotonin. Despite its effects on serotonin levels, it is not one of the SSRI class of drugs.

A potent neuropathic painkiller, Norpramin activates descending pathways in the spinal cord, which in turn inhibit upward-traveling pain signals, keeping them from reaching the brain. In addition to depression and neuropathic pain, Norpramin can be used to treat Attention Deficit Hyperactivity Disorder (ADHD). In this role, however, it is important to note that the drug largely only affects behavioral symptoms, leaving cognitive deficiencies un-addressed.

As with all tricyclic antidepressants, Norpramin causes a host of side effects, including dry mouth, anxiety, confusion, hypotension, nausea, and occasionally cardiac dysrhythmias. Many of these side effects can be managed and become less severe as continuing treatment progresses, or if initial doses are smaller and work gradually up to the appropriate clinical dose. Overdoses of Norpramin and other tricyclics can be cardiotoxic.

Norpramin should not be taken alongside certain other popular drugs, including fluoxetine and some antipsychotics. The mechanism of action for these drugs can cause a potentially dangerous buildup of Norpramin in the blood, leading to the aforementioned toxicity.

Once a popular staple for the treatment of depression and other conditions, Norpramin and the other tricyclics have mostly been replaced by SSRI, a class which presents few side effects, is better tolerated by more people, and has a lower risk of dangerous overdose.

Photo: Pixabay

Anxiety Support Groups

More Articles

While many anxiety disorders are very responsive to treatment, compulsive hoarding is a unique disorder which defies classification and tends to...

Everyone who has anxiety should have a few breathing techniques in their coping first aid kit.

The regular practice of controlled breathing...

Royce White has never been one to let obstacles get in the way of his dreams. An inspiring young man and stellar athlete, White was drafted by the...

Cortisol is a steroid hormone that is produced in response to stress, and it is a necessary part of the fight or flight response that helps the...

Practicing yoga regularly can be incredibly beneficial both mentally and physically. If you suffer from anxiety, stress, or depression yoga can be...

More Articles

Klonopin is the brand name of the generic drug clonazepam, a type of benzodiazepine. Benzodiazepines, which include drugs like Valium, Xanax, and...

The University of Central Florida newspaper published an article about an interesting clinical trial at the UCF Anxiety Disorders Clinic in the...

The expression "worried sick" caught on for a reason--it is not uncommon for anxiety to produce nausea as a symptom. Severe anxiety or fear cause...

Panic is real, and panic disorder is considered to be an illness. A panic attack is very painful and feelings of depression and helplessness may...

According to new research, T cells—best known for their role in fighting infections—may be one of the key players in elevated blood pressure...

As anyone who has experienced one knows, anxiety attacks are very frightening episodes of intense fear or panic. In addition to the severe...

Just because a thought visits your mind does not mean it is true. Negative thoughts about yourself and speculation about what’s going to happen...

It is true that what we eat affects our mood but also true that our mood affects how our food is digested. Thoughts, beliefs, feelings, and our...

Parnate, known generically as tranylcypromine, is an antidepressant of the class known as monoamine oxidase inhibitors (MAOIs). It is usually...

Part of going to school is taking tests, and you may be one of many students that experience intense test anxiety. This performance anxiety comes...

There are a lot of techniques and good advice available on how to overcome panic disorder, from watching what you eat and drink to changing the...

Perceived threats trigger the 'fight or flight' response—that sequential process that prepares you either to put up a fight to defend your life—...

One of the most prescribed drugs for the treatment of acute anxiety, valium has a host of other uses. It can treat alcohol withdrawal symptoms,...

What is stress?

Stress is sometimes used to describe challenges or threats, like, “Kelly was under a lot of stress”, or other times to...

There has been a reluctance to group video game addiction into the same category of other types of addiction, like drug or alcohol abuse, but the...