Anxiety Medication Overview of Norpramin

Norpramin is a tricyclic antidepressant that is approved by the FDA to treat depression and also prescribed off-label for the treatment of some anxiety disorders. It works by inhibiting the reuptake of norepinephrine and, to a lesser extent, serotonin. Norpramin and other tricyclic antidepressants are generally not considered first-line treatments, as the more recently introduced selective serotonin reuptake inhibitors (SSRIs) tend to have fewer side effects.

Common Side Effects

The most common side effects associated with Norpramin use are constipation, diarrhea, dizziness, drowsiness, dry mouth, headache, loss of appetite, nausea, tiredness, trouble sleeping, and weakness. Norpramin may also cause sensitivity to sunlight and may affect blood sugar levels. Some side effects, such as daytime drowsiness, can be reduced by taking the medication at bedtime.

Serious Adverse Effects

Norpramin has been associated with certain serious adverse effects, particularly cardiac arrhythmia, and should be used with caution in patients with a family history of sudden death, cardiac dysrhythmias, and cardiac conduction disturbances. It should not be used with children and used with caution in the elderly, as they may be more sensitive to its effects.

Other Severe Side Effects

Severe side effects may include (but are not limited to) allergic reactions, blurred vision, chest pain, confusion, difficulty speaking or swallowing, excessive sweating, fast or irregular heartbeat, mental or mood changes, numbness or tingling in an arm or leg, weakness on one side of the body, seizures, severe or persistent dizziness or headache, and yellowing of the skin or eyes.


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