Side Effects Overview of Parnate

The monoamine oxidase inhibitor (MAOI) tranylcypromine (brand name: Parnate) is an antidepressant sometimes used for the treatment of anxiety disorders. Like all medications, Parnate has the potential for side effects even when taken as directed.

Initially introduced in the U.S. in 1961, it was withdrawn from the market for a short time due to the serious side effect of high blood pressure that was fatal for some patients. It was soon reintroduced with more specific warnings and limited indications for use. While MAOIs are rarely the first medication used for depression and anxiety disorders due to their potential adverse effects, most people tolerate them fairly well and they are proven to be effective.

Side effects of tranylcypromine can include constipation, diarrhea, dry mouth, stomach pain, tremors, nausea, weakness, trouble sleeping, hypertension or hypotension, increased sweating, and changes in behavior or mood (such as feelings of anxiety, nervousness, irritability or hostility, impulsivity, or thoughts of suicide).

With all MAOIs, eating foods high in tyramine can lead to dangerously high blood pressure. Symptoms of this life-threatening situation include sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure, and sudden numbness or weakness.

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